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Degrees:
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Ph.D.
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Department:
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Neurological Surgery
Radiology
Radiation Oncology
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Research Center:
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Cancer Center
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Keywords:
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radiation biology, brain, apoptosis, radiotherapy, computed tomography, edema, blood-brain barrier
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Research Description:
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Radiation injury to normal brain is a potential complication of brain tumor therapy. A number of critical factors influence if or how radiation injury is expressed, and we are studying some of them in our laboratory endeavors. We are addressing parameters such as dose and irradiated volume and are determining if the effectiveness of a given treatment scheme can be modified using specific enzyme inhibitors or other biologically active compounds. Further, we are studying specific aspects of the pathogenesis of radiation injury, and are interested in a population of glial progenitor cells that reside in the subependymal region of the brain and that undergo apoptosis at relatively low doses. We employ different animal models and quantify the development and extent of injury using advanced imaging techniques and quantify cellular responses in vivo using immunohistochemical strategies to combat a clinically significant problem.
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Web Page:
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Selected Publications:
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1. Gobbel GT, Seilhan TM, Fike JR. Cerebrovascular response after interstitial irradiation. Radiat Res 1992;130:239-240.
2. Fike JR, Gobbel GT, Seilhan TM. Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine (DFMO). Radiat Res 1994;138:99-106.
3. Gobbel GT, Fike JR. A deconvolution method for evaluating indicator-dilution curves. Phys Biol Med 1994;39:1833-1854.
4. Fike JR, Gobbel GT, Chou D, Wijnhoven BPL, Bellinzona M, Nakagawa M, Seilhan TM. Cellular proliferation and infiltration following interstitial irradiation of normal dog brain is altered by an inhibitor of polyamine metabolism. Int J Radiat Oncol Biol Phys 1995;32:1035-1045.
5. Bellinzona M, Gobbel GT, Shinohara C, Fike JR. Apoptosis is induced in the subependyma of young adult rats by ionizing irradiation. Neurosci Letters 1996;208:163-166.
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Prerequisite for student research:
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