 |
|
Degrees:
|
M.D.
|
|
Department:
|
Pediatrics
|
|
Research Center:
|
Cancer Center
|
|
Keywords:
|
neuroblastoma, clinical trials, pediatric oncology, world health
|
|
Research Description:
|
I am Chief of Pediatric Oncology at UCSF and focus on clinical research using cell-specific treatments, particularly in treatment of neuroblastoma. I am a member of the Neuroblastoma Strategy Group in the Children's Oncology Group, a national organization of University and affiliate medical centers dedicated to clinical trials for the study and therapy of childhood cancer. Here at UCSF, I am studying [131 I]-MIBG, targeted radiotherapy for treatment of children with progressive neuroblastoma. In collaboration with the PCRC and nuclear medicine, we have already treated 31 patients on this protocol with 30% partial responses. We also participate in trials for autologous bone marrow transplantation in neuroblastoma, using purged marrow or peripheral blood stem cells. In addition, I am participating in other innovative phase I pilot studies for neuroblastoma treatment and in collaborative studies with basic research laboratories of neuroblastoma biology, both in molecular genetics and in immunology. Clincal research opportunities would be available analyzing these studies or other ongoing work in pediatric oncology.
|
|
Web Page:
|
|
|
Selected Publications:
|
1. Matthay KK, Huberty JP, Hattner RS, Ablin AR, Engelstad BL, Zoger S, Hasegawa BH, Price D. Efficacy and safety of [131I] Metaiodobenzylguanidine therapy for patients with refractory neuroblastoma. J Nucl Biol Med 1991;35:244-247.
2. Matthay KK, Seeger RC, Reynolds CP, Stram D, O'Leary M, Harris RE, Selch M, Atkinson J, Haase G, Hammond GD, Ramsay NK. Allogeneic vs. autologous purged bone marrow transplantation for neuroblastoma. J Clin Oncol 1994;12:2382-2389.
3. Shimada H, Stram DO, Chatten J, Joshi VV, Hachitanda Y, Brodeur GM, Lukens JN, Matthay KK, Seeger RC. Combined histopathologic and N-myc gene analysis identifies subsets of neuroblastoma. JNCI 1995;87:1472-1476.
4. Stram DO, Matthay KK, O'Leary M, Reynolds CP, Haase GM, Atkinson JB, Seeger RC. Consolidation chemoradiotherapy and autologous bone marrow transplantation vs. continued chemotherapy for metastatic neuroblastoma: A report of two concurrent Children's Cancer Group studies. J Clin Oncol, in press, 1996.
|
|
Prerequisite for student research:
|
Medicine 3 standing
|
|
|
|
