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Degrees:
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M.D.
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Department:
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Anesthesia and Perioperative Care
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Research Center:
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Anesthesia Research
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Keywords:
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anesthesia, alpha-2 agonists, sympathetic nervous system, hemodynamic, neurosurgery
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Research Description:
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My research is focused on the pharmacology and physiology of highly selective alpha-2 agonists. Alpha-2 agonists have sedative, analgesic and sympatholytic effects, and at high concentrations they are complete intravenous anesthetics. Since the development of two new highly selective alpha-2 agonists (dexmedetomidine and mivazerol), they have become one of the most innovative and interesting areas in anesthesia research.
My research involves both clinical and basic science projects. In 1992, I conducted the first clinical studies in the United States with both dexmedetomidine and mivazerol. Since then, I have conducted clinical studies in patients and healthy volunteers which investigated the perioperative effects of alpha-2 agonists on the cardiovascular system (heart rate, blood pressure, heart rate variability, and baroreflex), sympathetic nervous system (plasma and urine catecholamines), intracranial pressure, oxygen consumption, thermoregulation, interaction of alpha-2 agonists with muscle relaxants, and cerebrospinal fluid pharmacokinetics. In the area of my anesthetic subspecialty, I am also conducting selected clinical studies in neurosurgical anesthesia.
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Web Page:
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http://anesthesia.ucsf.edu/WebDocs/AnesFaculty/Talke.html
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Selected Publications:
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Talke P; Tong C; Lee H-W; Caldwell J; Eisenach J; Richardson CA. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in human. Anesthesia and Analgesia, 1997;85:358-64.
Talke P; Caldwell J; Dodsont B; Richardson CA. Desflurane and isoflurane increase lumbar cerebrospinal fluid pressure in normocapnic patients undergoing transsphenoidal hypophysectomy. Anesthesiology, 1996; 85:999-1004.
Talke P; Bickler PE. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology, 1996 85:551-7.
Talke P; Li J; Jain U; Leung J; Drasner K; Hollenberg M; Mangano DT. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anesthesiology, 1995; 82:620-33.
Talke P; Mangano DT. Alpha2-adrenergic agonists and peri-operative ischemia. Anesthetic Pharmacology Review 1993;1:310-15.
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Prerequisite for student research:
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Enthusiasm
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